What is the standard dosage for benzathine penicillin G in the treatment of tertiary syphilis?

• A. 1.04 million units IM in one dose
• B. 2.4 million units IM every week for three weeks
• C. 1 million units IM once a week
• D. 2.4 million units IM weekly for three weeks

Answer: (D)

The standard dosage for benzathine penicillin G in the treatment of tertiary syphilis is 2.4 million units administered intramuscularly once a week for three consecutive weeks. This dosage is based on established guidelines and reflects the clinical understanding of syphilis treatment protocols.

Tertiary syphilis requires an extended treatment regimen to effectively eradicate the infection, as it represents a more advanced stage of the disease, which can lead to severe complications if not treated properly. The choice of weekly administration is crucial for maintaining adequate drug levels in the body, ensuring that the treatment is both effective and minimizes the potential for resistance.

This regimen also aligns with clinical studies that have demonstrated the effectiveness of this dosage in achieving resolution of the disease while preventing potential complications associated with inadequate treatment.